Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens.

Parker, Kaveri S; Wilson, James D; Marschall, Jonas; Mucha, Peter J; Henderson, Jeffrey P (2015). Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens. ACS infectious diseases, 1(11), pp. 523-532. American Chemical Society 10.1021/acsinfecdis.5b00022

[img]
Preview
Text
acsinfecdis.pdf - Published Version
Available under License Publisher holds Copyright.

Download (3MB) | Preview

Increasing antibiotic resistance among uropathogenic Escherichia coli (UPEC) is driving interest in therapeutic targeting of nonconserved virulence factor (VF) genes. The ability to formulate efficacious combinations of antivirulence agents requires an improved understanding of how UPEC deploy these genes. To identify clinically relevant VF combinations, we applied contemporary network analysis and biclustering algorithms to VF profiles from a large, previously characterized inpatient clinical cohort. These mathematical approaches identified four stereotypical VF combinations with distinctive relationships to antibiotic resistance and patient sex that are independent of traditional phylogenetic grouping. Targeting resistance- or sex-associated VFs based upon these contemporary mathematical approaches may facilitate individualized anti-infective therapies and identify synergistic VF combinations in bacterial pathogens.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Marschall, Jonas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2373-8227

Publisher:

American Chemical Society

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

12 Apr 2016 16:51

Last Modified:

12 Apr 2016 16:51

Publisher DOI:

10.1021/acsinfecdis.5b00022

PubMed ID:

26985454

Uncontrolled Keywords:

UPEC; UTI; antibiotic resistance; network analysis; novel therapeutic targets; sex specificity in infections; uropathogens

BORIS DOI:

10.7892/boris.80310

URI:

https://boris.unibe.ch/id/eprint/80310

Actions (login required)

Edit item Edit item
Provide Feedback