Clinical Practice Recommendations For The Management And Prevention Of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers

Lee, Jong W; Pussegoda, Kusala; Rassekh, Rod S; Monzon, Jose G; Liu, Geoffrey; Hwang, Soomi; Bhavsar, Amit P; Pritchard, Sheila; Ross, Colin J; Carleton, Bruce C; Amstutz, Ursula (2016). Clinical Practice Recommendations For The Management And Prevention Of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers. Therapeutic drug monitoring, 38(4), p. 1. Lippincott Williams & Wilkins 10.1097/FTD.0000000000000298

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Currently no pharmacogenomics-based criteria exist to guide clinicians in identifying individuals who are at risk of hearing loss from cisplatin-based chemotherapy. This review summarizes findings from pharmacogenomic studies that report genetic polymorphisms associated with cisplatin-induced hearing loss and aims to (1) provide up-to-date information on new developments in the field; (2) provide recommendations for the use of pharmacogenetic testing in the prevention, assessment and management of cisplatin-induced hearing loss in children and adults; and (3) identify knowledge gaps to direct and prioritize future research. These practice recommendations for pharmacogenetic testing in the context of cisplatin-induced hearing loss reflect a review and evaluation of recent literature and are designed to assist clinicians in providing optimal clinical care for patients receiving cisplatin based chemotherapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Amstutz, Ursula

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0163-4356

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Ursula Amstutz

Date Deposited:

24 May 2016 09:29

Last Modified:

06 Mar 2017 02:30

Publisher DOI:

10.1097/FTD.0000000000000298

PubMed ID:

26960170

BORIS DOI:

10.7892/boris.80349

URI:

https://boris.unibe.ch/id/eprint/80349

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