Winter, Annja; Letang, Emilio; Kalinjuma, Aneth Vedastus; Kimera, Namvua; Ntamatungiro, Alex; Glass, Tracy; Moradpour, Darius; Sahli, Roland; Le Gal, Frédéric; Furrer, Hansjakob; Wandeler, Gilles (2016). Absence of Hepatitis Delta Infection in a Large Rural HIV Cohort in Tanzania. International journal of infectious diseases, 46, pp. 8-10. Elsevier 10.1016/j.ijid.2016.03.011
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OBJECTIVES
The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in sub-Saharan Africa are ill-defined. We determined the prevalence of HDV infection in HIV/hepatitis B virus (HBV)-co-infected individuals in rural Tanzania.
DESIGN AND METHODS
We screened all hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) for anti-HDV antibodies. In positive samples, we performed a second serological test and nucleic acid amplification. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients.
RESULTS
Among 222 HIV/HBV-coinfected patients on ART, 219 (98.6%) had a stored serum sample available and were included. Median age was 37 years, 55% were female, 46% had WHO stage III/IV HIV disease and median CD4 count was 179 cells/μL. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8%-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them.
CONCLUSIONS
We found no confirmed case of HDV infection among over 200 HIV/HBV-co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Winter, Annja (A), Furrer, Hansjakob, Wandeler, Gilles |
Subjects: |
300 Social sciences, sociology & anthropology > 360 Social problems & social services 600 Technology > 610 Medicine & health |
ISSN: |
1201-9712 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
08 Jun 2016 12:12 |
Last Modified: |
29 Mar 2023 23:34 |
Publisher DOI: |
10.1016/j.ijid.2016.03.011 |
PubMed ID: |
26996457 |
Uncontrolled Keywords: |
False-positive serology; HIV; Hepatitis delta; Sub-Saharan Africa; Tanzania |
BORIS DOI: |
10.7892/boris.80401 |
URI: |
https://boris.unibe.ch/id/eprint/80401 |
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