Absence of Hepatitis Delta Infection in a Large Rural HIV Cohort in Tanzania

Winter, Annja; Letang, Emilio; Kalinjuma, Aneth Vedastus; Kimera, Namvua; Ntamatungiro, Alex; Glass, Tracy; Moradpour, Darius; Sahli, Roland; Le Gal, Frédéric; Furrer, Hansjakob; Wandeler, Gilles (2016). Absence of Hepatitis Delta Infection in a Large Rural HIV Cohort in Tanzania. International Journal of Infectious Diseases; IJID, 46, pp. 8-10. Elsevier 10.1016/j.ijid.2016.03.011

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OBJECTIVES The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in sub-Saharan Africa are ill-defined. We determined the prevalence of HDV infection in HIV/hepatitis B virus (HBV)-co-infected individuals in rural Tanzania. DESIGN AND METHODS We screened all hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) for anti-HDV antibodies. In positive samples, we performed a second serological test and nucleic acid amplification. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS Among 222 HIV/HBV-coinfected patients on ART, 219 (98.6%) had a stored serum sample available and were included. Median age was 37 years, 55% were female, 46% had WHO stage III/IV HIV disease and median CD4 count was 179 cells/μL. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8%-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS We found no confirmed case of HDV infection among over 200 HIV/HBV-co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Winter, Annja; Furrer, Hansjakob and Wandeler, Gilles

Subjects:

300 Social sciences, sociology & anthropology > 360 Social problems & social services
600 Technology > 610 Medicine & health

ISSN:

1201-9712

Publisher:

Elsevier

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

08 Jun 2016 12:12

Last Modified:

09 Jun 2016 16:20

Publisher DOI:

10.1016/j.ijid.2016.03.011

PubMed ID:

26996457

Uncontrolled Keywords:

False-positive serology; HIV; Hepatitis delta; Sub-Saharan Africa; Tanzania

BORIS DOI:

10.7892/boris.80401

URI:

https://boris.unibe.ch/id/eprint/80401

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