Phylogenetic analysis of receptor FgfrL1 shows divergence of the C-terminal end in rodents

Zhuang, Lei; Bluteau, Gilles; Trueb, Beat (2015). Phylogenetic analysis of receptor FgfrL1 shows divergence of the C-terminal end in rodents. Comparative biochemistry and physiology. Part B - biochemistry & molecular biology, 186, pp. 43-50. Elsevier 10.1016/j.cbpb.2015.04.009

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FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family. Similar to the classical receptors FGFR1-FGFR4, it contains three extracellular Ig-like domains and a single transmembrane domain. However, it lacks the intracellular tyrosine kinase domain that would be required for signal transduction, but instead contains a short intracellular tail with a peculiar histidine-rich motif. This motif has been conserved during evolution from mollusks to echinoderms and vertebrates. Only the sequences of FgfrL1 from a few rodents diverge at the C-terminal region from the canonical sequence, as they appear to have suffered a frameshift mutation within the histidine-rich motif. This mutation is observed in mouse, rat and hamster, but not in the closely related rodents mole rat (Nannospalax) and jerboa (Jaculus), suggesting that it has occurred after branching of the Muridae and Cricetidae from the Dipodidae and Spalacidae. The consequence of the frameshift is a deletion of a few histidine residues and an extension of the C-terminus by about 40 unrelated amino acids. A similar frameshift mutation has also been observed in a human patient with a craniosynostosis syndrome as well as in several patients with colorectal cancer and bladder tumors, suggesting that the histidine-rich motif is prone to mutation. The reason why this motif was conserved during evolution in most species, but not in mice, is not clear.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

UniBE Contributor:

Zhuang, Lei; Bluteau, Gilles and Trueb, Beat

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1096-4959

Publisher:

Elsevier

Language:

English

Submitter:

Stefan Kuchen

Date Deposited:

13 Apr 2016 16:38

Last Modified:

13 Apr 2016 16:38

Publisher DOI:

10.1016/j.cbpb.2015.04.009

PubMed ID:

25934085

Uncontrolled Keywords:

FGFRL1; Fibroblast growth factor (FGF); Fibroblast growth factor receptor (FGFR); Histidine-rich motif; Rodents

BORIS DOI:

10.7892/boris.80937

URI:

https://boris.unibe.ch/id/eprint/80937

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