Biology of Bone Metastases in Prostate Cancer

Hensel, Janine; Thalmann, George (2016). Biology of Bone Metastases in Prostate Cancer. Urology, 92, pp. 6-13. Elsevier 10.1016/j.urology.2015.12.039

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Advanced-stage prostate cancer (PCa) patients are often diagnosed with bone metastases. Bone metastases remain incurable and therapies are palliative. PCa cells prevalently cause osteoblastic lesions, characterized by an excess of bone formation. The prevailing concept indicates that PCa cancer cell secrete an excess of paracrine factors stimulating osteoblasts directly or indirectly, thereby leading to an excess of bone formation. The exact mechanisms by which bone formation stimulates PCa cell growth are mostly elusive. In this review, the mechanisms of PCa cancer cell osteotropism, the cancer cell-induced response within the bone marrow/bone stroma, and therapeutic stromal targets will be summarized.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

UniBE Contributor:

Hensel, Janine and Thalmann, George

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0090-4295

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

08 Jun 2016 11:12

Last Modified:

20 Sep 2017 19:03

Publisher DOI:

10.1016/j.urology.2015.12.039

PubMed ID:

26768714

BORIS DOI:

10.7892/boris.80966

URI:

https://boris.unibe.ch/id/eprint/80966

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