Lipid topogenesis - 35 years on

Chauhan, Neha; Farine, Luce; Pandey, Kalpana; Menon, Anant K; Bütikofer, Peter (2016). Lipid topogenesis - 35 years on. Biochimica et biophysica acta (BBA) - molecular and cell biology of lipids, 1861(8), pp. 757-766. Elsevier 10.1016/j.bbalip.2016.02.025

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Glycerophospholipids are the principal fabric of cellular membranes. The pathways by which these lipids are synthesized were elucidated mainly through the work of Kennedy and colleagues in the late 1950s and early 1960s. Subsequently, attention turned to cell biological aspects of lipids: Where in the cell are lipids synthesized? How are lipids integrated into membranes to form a bilayer? How are they sorted and transported from their site of synthesis to other cellular destinations? These topics, collectively termed 'lipid topogenesis', were the subject of a review article in 1981 by Bell, Ballas and Coleman. We now assess what has been learned about early events of lipid topogenesis, i.e. "lipid synthesis, the integration of lipids into membranes, and lipid translocation across membranes", in the 35years since the publication of this important review. We highlight the recent elucidation of the X-ray structures of key membrane enzymes of glycerophospholipid synthesis, progress on identifying lipid scramblase proteins needed to equilibrate lipids across membranes, and new complexities in the subcellular location and membrane topology of phosphatidylinositol synthesis revealed through a comparison of two unicellular model eukaryotes.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Farine, Luce and Bütikofer, Peter


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








Barbara Järmann-Bangerter

Date Deposited:

08 Jun 2016 12:06

Last Modified:

22 Sep 2017 08:56

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

CDP-alcohol; Endoplasmic reticulum; Kennedy pathway; Membrane protein; Phospholipid; Scramblase




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