Three-year results of visual outcome with disease activity-guided ranibizumab algorithm for the treatment of exudative age-related macular degeneration

Lala, Ceklic; Framme, Carsten; Wolf-Schnurrbusch, Ute E. K.; Wolf, Sebastian (2012). Three-year results of visual outcome with disease activity-guided ranibizumab algorithm for the treatment of exudative age-related macular degeneration. Acta ophthalmologica, 91(6), pp. 526-530. Oxford: Blackwell Munksgaard 10.1111/j.1755-3768.2012.02457.x

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PURPOSE To evaluate 3-year follow-up treatment outcomes with ranibizumab (Lucentis(®)) 0.5 mg administered either monthly or quarterly on a pro re nata (PRN) basis according to a disease activity-guided monitoring and treatment algorithm. METHODS A total of 316 treatment-naive eyes of 316 patients with exudative age-related macular degeneration met the criteria for inclusion in this retrospective, interventional case series. Patients were treated with ranibizumab 0.5 mg according to a disease activity-guided algorithm with monthly monitoring. Optical coherence tomography and fluorescein angiography were routinely used to assess disease activity: active lesions were treated with a series of three monthly injections, whereas inactive lesions were treated with quarterly injections. RESULTS Mean Early Treatment Diabetic Retinopathy Study best-corrected visual acuity improved from 52 letters at baseline to 59 letters at 12 months, achieved with a mean of 7.1 injections, 61 letters at 24 months with a mean of 5.0 injections administered in the second year and 60 letters at 36 months with a mean number of 5.2 injections. CONCLUSIONS Monthly visits and a morphology-driven PRN regimen with 3 injections in case of recurrence plus quarterly injections in case of inactive CNV resulted in an average VA gain of 7-9 letters that could be maintained over 3 years.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Framme, Carsten Karl Josef; Wolf-Schnurrbusch, Ute and Wolf, Sebastian

ISSN:

1755-375X

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

12 May 2014 10:48

Publisher DOI:

10.1111/j.1755-3768.2012.02457.x

PubMed ID:

22697404

Web of Science ID:

000323201500025

Uncontrolled Keywords:

antivascular endothelial growth factor, exudative age-related macular degeneration, optical coherence tomography, visual acuity

URI:

https://boris.unibe.ch/id/eprint/8108 (FactScience: 213590)

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