The Role of Platelets in Venous Thromboembolism

Montoro-García, Silvia; Schindewolf, Marc; Stanford, Sophia; Larsen, Ole Halfdan; Thiele, Thomas (2016). The Role of Platelets in Venous Thromboembolism. Seminars in thrombosis and hemostasis, 42(3), pp. 242-251. Thieme Medical Publishers 10.1055/s-0035-1570079

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Multiple factors contribute to the risk of venous thromboembolism (VTE). Platelets have attracted much interest in arterial cardiovascular disease, whereas their role in VTE has received much less attention. Recent evidence suggests that platelets may play a more important role in VTE than previously anticipated. This review discusses the mechanisms that link platelets with venous thrombotic disease and their potential applications as novel risk factors for VTE. In addition, animal studies and randomized clinical trials that highlight the potential effect of antiplatelet therapy in venous thrombosis are evaluated to assess the role of platelets in VTE. The clinical significance of platelets for VTE risk assessment in specific patient cohorts and their role as a suitable therapeutic target for VTE prevention is acknowledged. The role of platelets in VTE is a promising field for future research.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Schindewolf, Marc

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0094-6176

Publisher:

Thieme Medical Publishers

Language:

English

Submitter:

Catherine Gut

Date Deposited:

08 Jun 2016 12:43

Last Modified:

22 Sep 2017 08:53

Publisher DOI:

10.1055/s-0035-1570079

PubMed ID:

26926584

BORIS DOI:

10.7892/boris.81099

URI:

https://boris.unibe.ch/id/eprint/81099

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