Steerable intravitreal inserts for drug delivery: in vitro and ex vivo mobility experiments

Bergeles, Christos; Kummer, Michael P; Kratochvil, Bradley E; Framme, Carsten; Nelson, Bradley J (2011). Steerable intravitreal inserts for drug delivery: in vitro and ex vivo mobility experiments. In: Fichtinger, Gabor; Martel, Anna; Peters, Terry (eds.) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2011. Lecture Notes in Computer Science: Vol. 6891 (pp. 33-40). Berlin: Springer 10.1007/978-3-642-23623-5_5

Full text not available from this repository. (Request a copy)

The progress of wet age-related macular degeneration can now be controlled by intravitreal drug injection. This approach requires repeated injections, which could be avoided by delivering the drug to the retina. Intraocular implants are a promising solution for drug delivery near the retina. Currently, their accurate placement is challenging, and they can only be removed after a vitrectomy. In this paper, we introduce an approach for minimally invasive retinal drug delivery using magnetic intraocular inserts. We briefly discuss the electromagnetic-control system for magnetic implants and then focus on evaluating their ability to move in the vitreous humor. The mobility of magnetic intraocular implants is estimated in vitro with synthesized vitreous humors, and ex vivo with experiments on cadaver porcine eyes. Preliminary results show that with such magnetic implants a vitrectomy can be avoided.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Framme, Carsten Karl Josef

ISSN:

0302-9743

ISBN:

978-3-642-23623-5

Series:

Lecture Notes in Computer Science

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

04 May 2014 02:04

Publisher DOI:

10.1007/978-3-642-23623-5_5

PubMed ID:

22003597

Web of Science ID:

000306990000005

URI:

https://boris.unibe.ch/id/eprint/8113 (FactScience: 213595)

Actions (login required)

Edit item Edit item
Provide Feedback