Non-canonical actions of Nogo-A and its receptors

Seiler, Stefanie; Di Santo, Stefano; Widmer, Hans Rudolf (2016). Non-canonical actions of Nogo-A and its receptors. Biochemical pharmacology, 100, pp. 28-39. Elsevier 10.1016/j.bcp.2015.08.113

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Nogo-A is a myelin associated protein and one of the most potent neurite growth inhibitors in the central nervous system. Interference with Nogo-A signaling has thus been investigated as therapeutic target to promote functional recovery in CNS injuries. Still, the finding that Nogo-A presents a fairly ubiquitous expression in many types of neurons in different brain regions, in the eye and even in the inner ear suggests for further functions besides the neurite growth repression. Indeed, a growing number of studies identified a variety of functions including regulation of neuronal stem cells, modulation of microglial activity, inhibition of angiogenesis and interference with memory formation. Aim of the present commentary is to draw attention on these less well-known and sometimes controversial roles of Nogo-A. Furthermore, we are addressing the role of Nogo-A in neuropathological conditions such as ischemic stroke, schizophrenia and neurodegenerative diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Seiler, Stefanie; Di Santo, Stefano and Widmer, Hans Rudolf

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0006-2952

Publisher:

Elsevier

Language:

English

Submitter:

Nicole Söll

Date Deposited:

09 Jun 2016 09:33

Last Modified:

30 Sep 2017 09:16

Publisher DOI:

10.1016/j.bcp.2015.08.113

PubMed ID:

26348872

Uncontrolled Keywords:

Cell signaling; Distribution; Neurodegenerative diseases; Nogo-A; Nogo-receptor; Regenerative medicine

BORIS DOI:

10.7892/boris.81171

URI:

https://boris.unibe.ch/id/eprint/81171

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