Directional DBS improves therapeutic window: from model prediction to human use

Pollo, Claudio; Kaelin, Alain; Oertel, Markus Florian; Stieglitz, Lennart; Rossi-Mossuti, Frédéric Gianfranco Gualtiero; Lozano, A; Raabe, Andreas; Schüpbach, Michael (2015). Directional DBS improves therapeutic window: from model prediction to human use. Brain stimulation, 8(2), pp. 380-381. Elsevier 10.1016/j.brs.2015.01.218

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Deep brain stimulation of different targets has been shown to drastically improve symptoms of a variety of neurological conditions. However, the occurrence of disabling side effects may limit the ability to deliver adequate amounts of current necessary to reach the maximal benefit. Computed models have suggested that reduction in electrode size and the ability to provide directional stimulation could increase the efficacy of such therapies. This has never been demonstrated in humans. In the present study, we assess the effect of directional stimulation compared to omnidirectional stimulation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Pollo, Claudio; Kaelin, Alain; Oertel, Markus Florian; Stieglitz, Lennart; Rossi-Mossuti, Frédéric Gianfranco Gualtiero; Raabe, Andreas and Schüpbach, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1935-861X

Publisher:

Elsevier

Language:

English

Submitter:

Nicole Söll

Date Deposited:

20 Apr 2016 17:08

Last Modified:

21 Apr 2016 22:54

Publisher DOI:

10.1016/j.brs.2015.01.218

BORIS DOI:

10.7892/boris.81174

URI:

https://boris.unibe.ch/id/eprint/81174

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