Higher macrophage superoxide anion production in coronary artery disease (CAD) patients with Type D personality

Hackl, Claudia; von Känel, Roland; Thomas, Livia; Kübler, Peggy; Schmid, Jean-Paul; Mattle, Heinrich P.; Mono, Marie-Luise; Rieben, Robert; Wiest, Roland; Wirtz, Petra H. (2016). Higher macrophage superoxide anion production in coronary artery disease (CAD) patients with Type D personality. Psychoneuroendocrinology, 68, pp. 186-193. Elsevier 10.1016/j.psyneuen.2016.02.031

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BACKGROUND Type D personality (Type D) is an independent psychosocial risk factor for poor cardiac prognosis and increased mortality in patients with cardiovascular disease (CVD), but the involved mechanisms are poorly understood. Macrophages play a pivotal role in atherosclerosis, the process underlying coronary artery disease (CAD). We investigated macrophage superoxide anion production in production in CAD patients with and without Type D. METHODS AND RESULTS We studied 20 male CAD patients with Type D (M:66.7±9.9years) and 20 age-matched male CAD patients without Type D (M:67.7±8.5years). Type D was measured using the DS14 questionnaire with the two subscales 'negative affectivity' and 'social inhibition'. We assessed macrophage superoxide anion production using the WST-1 assay. All analyses were controlled for potential confounders. CAD patients with Type D showed higher superoxide anion production compared to CAD patients without Type D (F(1,38)=15.57, p<0.001). Complementary analyses using the Type D subscales 'negative affectivity' and 'social inhibition', and their interaction as continuous measures, showed that both Type D subscales (negative affectivity: (ß=0.48, p=0.002, R(2)=0.227); social inhibition: (ß=0.46, p=0.003, R(2)=0.208)) and their interaction (ß=0.36, p=0.022, R(2)=0.130) were associated with higher WST-1 reduction scores. Results remained significant when controlling for classical CVD risk factors (i.e. body mass index, mean arterial blood pressure), atherosclerosis severity (i.e. intima media thickness, presence of carotid plaques), and psychological factors (depressive symptom severity, chronic stress). CONCLUSIONS Our results indicate higher macrophage superoxide anion production in CAD patients with Type D compared to those without Type D. This may suggest a mechanism contributing to increased morbidity and mortality in CAD patients with Type D.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe

UniBE Contributor:

Hackl, Claudia; von Känel, Roland; Thomas, Livia; Kübler, Peggy; Schmid, Jean-Paul; Mattle, Heinrich; Mono, Marie-Luise; Rieben, Robert; Wiest, Roland and Wirtz, Petra Hedwig

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology
300 Social sciences, sociology & anthropology

ISSN:

0306-4530

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

11 May 2016 09:47

Last Modified:

20 Feb 2019 09:34

Publisher DOI:

10.1016/j.psyneuen.2016.02.031

PubMed ID:

26994482

Uncontrolled Keywords:

CAD, Human macrophages, NADPH oxidase, Superoxide anions, Type D personality

BORIS DOI:

10.7892/boris.81250

URI:

https://boris.unibe.ch/id/eprint/81250

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