Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

Dill, Michael T; Rothweiler, Sonja; Djonov, Valentin; Hlushchuk, Ruslan; Tornillo, Luigi; Terracciano, Luigi; Meili-Butz, Silvia; Radtke, Freddy; Heim, Markus H; Semela, David (2012). Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice. Gastroenterology, 142(4), 967-977.e2. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2011.12.052

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Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Djonov, Valentin and Hlushchuk, Ruslan

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

17 Mar 2015 21:03

Publisher DOI:

10.1053/j.gastro.2011.12.052

PubMed ID:

22245843

Web of Science ID:

000302296400046

URI:

https://boris.unibe.ch/id/eprint/8132 (FactScience: 213617)

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