Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults.

Bracht, Tobias; Jones, Derek K; Bells, Sonya; Walther, Sebastian; Drakesmith, Mark; Linden, David (2016). Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults. Brain structure & function, 221(9), pp. 4537-4548. Springer 10.1007/s00429-016-1183-3

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Recent evidence suggests that individual differences in physical activity (PA) may be associated with individual differences in white matter microstructure and with grey matter volume of the hippocampus. Therefore, this study investigated the association between PA and white matter microstructure of pathways connecting to the hippocampus. A total of 33 young, healthy adults underwent magnetic resonance imaging (MRI). High angular resolution diffusion-weighted imaging and multi-component relaxometry MRI scans (multi-component driven equilibrium pulse observation of T1 and T2) were acquired for each participant. Activity levels (AL) of participants were calculated from 72-h actigraphy recordings. Tractography using the damped Richardson Lucy algorithm was used to reconstruct the fornix and bilateral parahippocampal cinguli (PHC). The mean fractional anisotropy (FA) and the myelin water fraction (MWF), a putative marker of myelination, were determined for each pathway. A positive correlation between both AL and FA and between AL and MWF were hypothesized for the three pathways. There was a selective positive correlation between AL and MWF in the right PHC (r = 0.482, p = 0.007). Thus, our results provide initial in vivo evidence for an association between myelination of the right PHC and PA in young healthy adults. Our results suggest that MWF may not only be more specific, but also more sensitive than FA to detect white matter microstructural alterations. If PA was to induce structural plasticity of the right PHC this may contribute to reverse structural alterations of the right PHC in neuropsychiatric disorder with hippocampal pathologies.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Bracht, Tobias and Walther, Sebastian


600 Technology > 610 Medicine & health








Sebastian Walther

Date Deposited:

09 Jun 2016 11:07

Last Modified:

11 Jan 2017 08:59

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Actigraphy; Activity; Diffusion tensor imaging; Hippocampus; Neuroplasticity; White matter




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