Gut Microbiota Orchestrates Energy Homeostasis during Cold.

Chevalier, Claire; Stojanović, Ozren; Colin, Didier J; Suarez-Zamorano, Nicolas; Tarallo, Valentina; Veyrat-Durebex, Christelle; Rigo, Dorothée; Fabbiano, Salvatore; Stevanović, Ana; Hagemann, Stefanie Claudia; Montet, Xavier; Seimbille, Yann; Zamboni, Nicola; Hapfelmeier, Siegfried Hektor; Trajkovski, Mirko (2015). Gut Microbiota Orchestrates Energy Homeostasis during Cold. Cell, 163(6), pp. 1360-1374. Cell Press 10.1016/j.cell.2015.11.004

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Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host and enable tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold, however, the body weight loss is attenuated, caused by adaptive mechanisms maximizing caloric uptake and increasing intestinal, villi, and microvilli lengths. This increased absorptive surface is transferable with the cold microbiota, leading to altered intestinal gene expression promoting tissue remodeling and suppression of apoptosis-the effect diminished by co-transplanting the most cold-downregulated strain Akkermansia muciniphila during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Hagemann, Stefanie Claudia and Hapfelmeier, Siegfried Hektor

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0092-8674

Publisher:

Cell Press

Language:

English

Submitter:

Siegfried Hektor Hapfelmeier-Balmer

Date Deposited:

26 Apr 2016 09:31

Last Modified:

21 Dec 2016 10:09

Publisher DOI:

10.1016/j.cell.2015.11.004

PubMed ID:

26638070

BORIS DOI:

10.7892/boris.81377

URI:

https://boris.unibe.ch/id/eprint/81377

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