Effects of subthalamic nucleus stimulation on cognition and mood in Parkinson’s disease (PD)

Häner, J. D.; Schüpbach, M. W. M.; Stephan, M. A.; Gutbrod, K.; Kaelin-Lang, A. (27 May 2009). Effects of subthalamic nucleus stimulation on cognition and mood in Parkinson’s disease (PD). Movement disorders, 24(S1), S465-S465. Wiley-Blackwell 10.1002/mds.22628

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Objective: To assess the neuropsychological outcome as a safety measure and quality control in patients with subthalamic nucleus (STN) stimulation for PD. Background: Deep brain stimulation (DBS) is considered a relatively safe treatment used in patients with movement disorders. However, neuropsychological alterations have been reported in patients with STN DBS for PD. Cognition and mood are important determinants of quality of life in PD patients and must be assessed for safety control. Methods: Seventeen consecutive patients (8 women) who underwent STN DBS for PD have been assessed before and 4 months after surgery. Besides motor symptoms (UPDRS-III), mood (Beck Depression Inventory, Hamilton Depression Rating Scale) and neuropsychological aspects, mainly executive functions, have been assessed (mini mental state examination, semantic and phonematic verbal fluency, go-no go test, stroop test, trail making test, tests of alertness and attention, digit span, wordlist learning, praxia, Boston naming test, figure drawing, visual perception). Paired t-tests were used for comparisons before and after surgery. Results: Patients were 61.6±7.8 years old at baseline assessment. All surgeries were performed without major adverse events. Motor symptoms ‘‘on’’ medication remained stable whereas they improved in the ‘‘off’’ condition (p<0.001). Mood was not depressed before surgery and remained unchanged at follow-up. All neuropsychological assessment outcome measures remained stable at follow-up with the exception of semantic verbal fluency and wordlist learning. Semantic verbal fluency decreased by 21±16% (p<0.001) and there was a trend to worse phonematic verbal fluency after surgery (p=0.06). Recall of a list of 10 words was worse after surgery only for the third attempt of recall (13%, p<0.005). Conclusions: Verbal fluency decreased in our patients after STN DBS, as previously reported. The procedure was otherwise safe and did not lead to deterioration of mood.

Item Type:

Conference or Workshop Item (Poster)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology > Psychological and Behavioral Health

UniBE Contributor:

Häner, Jonas Dominik; Schüpbach, Michael; Stephan, Marianne; Gutbrod, Klemens and Kaelin, Alain


600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology








Jonas Häner

Date Deposited:

09 Jun 2016 12:15

Last Modified:

11 Sep 2017 18:48

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