Correlation between alveolar ventilation and electrical properties of lung parenchyma.

Roth, Christian J; Ehrl, Andreas; Becher, Tobias; Frerichs, Inéz; Schittny, Johannes; Weiler, Norbert; Wall, Wolfgang A (2015). Correlation between alveolar ventilation and electrical properties of lung parenchyma. Physiological measurement, 36(6), pp. 1211-1226. Institute of Physics Publishing IOP 10.1088/0967-3334/36/6/1211

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One key problem in modern medical imaging is linking measured data and actual physiological quantities. In this article we derive such a link between the electrical bioimpedance of lung parenchyma, which can be measured by electrical impedance tomography (EIT), and the magnitude of regional ventilation, a key to understanding lung mechanics and developing novel protective ventilation strategies. Two rat-derived three-dimensional alveolar microstructures obtained from synchrotron-based x-ray tomography are each exposed to a constant potential difference for different states of ventilation in a finite element simulation. While the alveolar wall volume remains constant during stretch, the enclosed air volume varies, similar to the lung volume during ventilation. The enclosed air, serving as insulator in the alveolar ensemble, determines the resulting current and accordingly local tissue bioimpedance. From this we can derive a relationship between lung tissue bioimpedance and regional alveolar ventilation. The derived relationship shows a linear dependence between air content and tissue impedance and matches clinical data determined from a ventilated patient at the bedside.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Schittny, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0967-3334

Publisher:

Institute of Physics Publishing IOP

Language:

English

Submitter:

Benoît Zuber

Date Deposited:

28 Apr 2016 08:56

Last Modified:

28 Apr 2016 08:56

Publisher DOI:

10.1088/0967-3334/36/6/1211

PubMed ID:

26008964

BORIS DOI:

10.7892/boris.81396

URI:

https://boris.unibe.ch/id/eprint/81396

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