Greganova, Eva; Altmann, Michael; Bütikofer, Peter (2011). Unique modifications of translation elongation factors. FEBS journal, 278(15), pp. 2613-24. Oxford: Wiley-Blackwell 10.1111/j.1742-4658.2011.08199.x
Full text not available from this repository. (Request a copy)Covalent modifications of proteins often modulate their biological functions or change their subcellular location. Among the many known protein modifications, three are exceptional in that they only occur on single proteins: ethanolamine phosphoglycerol, diphthamide and hypusine. Remarkably, the corresponding proteins carrying these modifications, elongation factor 1A, elongation factor 2 and initiation factor 5A, are all involved in elongation steps of translation. For diphthamide and, in part, hypusine, functional essentiality has been demonstrated, whereas no functional role has been reported so far for ethanolamine phosphoglycerol. We review the biosynthesis, attachment and physiological roles of these unique protein modifications and discuss common and separate features of the target proteins, which represent essential proteins in all organisms.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Altmann, Michael, Bütikofer, Peter |
ISSN: |
1742-464X |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:23 |
Last Modified: |
05 Dec 2022 14:06 |
Publisher DOI: |
10.1111/j.1742-4658.2011.08199.x |
PubMed ID: |
21624055 |
Web of Science ID: |
000292933300001 |
URI: |
https://boris.unibe.ch/id/eprint/8142 (FactScience: 213629) |
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