Transcranial magnetic stimulation (TMS) inhibits cortical dendrites

Murphy, Sean C; Palmer, Lucy; Nyffeler, Thomas; Müri, René Martin; Larkum, Matthew (2016). Transcranial magnetic stimulation (TMS) inhibits cortical dendrites. eLife, 5, e13598. eLife Sciences Publications 10.7554/eLife.13598

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One of the leading approaches to non-invasively treat a variety of brain disorders is transcranial magnetic stimulation (TMS). However, despite its clinical prevalence, very little is known about the action of TMS at the cellular level let alone what effect it might have at the subcellular level (e.g. dendrites). Here, we examine the effect of single-pulse TMS on dendritic activity in layer 5 pyramidal neurons of the somatosensory cortex using an optical fiber imaging approach. We find that TMS causes GABAB-mediated inhibition of sensory-evoked dendritic Ca(2+) activity. We conclude that TMS directly activates fibers within the upper cortical layers that leads to the activation of dendrite-targeting inhibitory neurons which in turn suppress dendritic Ca(2+) activity. This result implies a specificity of TMS at the dendritic level that could in principle be exploited for investigating these structures non-invasively.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Palmer, Lucy; Nyffeler, Thomas; Müri, René Martin and Larkum, Matthew

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2050-084X

Publisher:

eLife Sciences Publications

Language:

English

Submitter:

Vanessa Vallejo

Date Deposited:

25 May 2016 14:42

Last Modified:

10 Jan 2017 11:28

Publisher DOI:

10.7554/eLife.13598

PubMed ID:

26988796

Uncontrolled Keywords:

GABAB inhibition; dendritic integration; in vivo; neuroscience; rat; transcranial magnetic stimulation

BORIS DOI:

10.7892/boris.81437

URI:

https://boris.unibe.ch/id/eprint/81437

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