Type A aortic dissection model to improve endovascular research and technologies.

Heinisch, Paul Philipp; Winkler, Bernhard; Weidenhagen, Rolf; Klaws, Rolf; Carrel, Thierry; Khoynezhad, Ali; Bombien, Rene (2016). Type A aortic dissection model to improve endovascular research and technologies. Asian cardiovascular and thoracic annals, 24(4), pp. 337-343. Sage 10.1177/0218492316641288

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OBJECTIVE Type A aortic dissection is a life-threatening disease requiring immediate surgical treatment. With emerging catheter-based technologies, endovascular stent-graft implantation to treat aneurysms and dissections has become a standardized procedure. However, endovascular treatment of the ascending aorta remains challenging. Thus we designed an ascending aortic dissection model to allow simulation of endovascular treatment. METHODS Five formalin-fixed human aortas were prepared. The ascending aorta was opened semicircularly in the middle portion and the medial layer was separated from the intima. The intimal tube was readapted using running monofilament sutures. The preparations were assessed by 128-slice computed tomography. A bare-metal stent was implanted for thoracic endovascular aortic repair in 4 of the aortic dissection models. RESULTS Separation of the intimal and medial layer of the aorta was considered to be sufficient because computed tomography showed a clear image of the dissection membrane in each aorta. The dissection was located 3.9 ± 1.4 cm proximally from the aortic annulus, with a length of 4.6 ± 0.9 cm. Before stent implantation, the mean distance from the intimal flap to the aortic wall was measured as 0.63 ± 0.163 cm in the ascending aorta. After stent implantation, this distance decreased to 0.26 ± 0.12 cm. CONCLUSION This model of aortic dissection of the ascending human aorta was reproducible with a comparable pathological and morphological appearance. The technique and model can be used to evaluate new stent-graft technologies to treat type A dissection and facilitate training for surgeons.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Heinisch, Paul Philipp; Winkler, Bernhard and Carrel, Thierry


600 Technology > 610 Medicine & health








Daniela Huber

Date Deposited:

30 Jun 2016 10:31

Last Modified:

30 Jun 2016 10:31

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Aneurysm; Endovascular procedures; In vitro techniques; Stents; Vascular surgical procedures dissecting





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