Immunoregulation in larval Echinococcus multilocularis infection.

Wang, Junhua; Gottstein, Bruno (2016). Immunoregulation in larval Echinococcus multilocularis infection. Parasite immunology, 38(3), pp. 182-192. Blackwell Scientific Publications 10.1111/pim.12292

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Alveolar echinococcosis (AE) is a clinically very severe zoonotic helminthic disease, characterized by a chronic progressive hepatic damage caused by the continuous proliferation of the larval stage (metacestode) of Echinococcus multilocularis. The proliferative potential of the parasite metacestode tissue is dependent on the nature/function of the periparasitic immune-mediated processes of the host. Immune tolerance and/or down-regulation of immunity are a marked characteristic increasingly observed when disease develops towards its chronic (late) stage of infection. In this context, explorative studies have clearly shown that T regulatory (Treg) cells play an important role in modulating and orchestrating inflammatory/immune reactions in AE, yielding a largely Th2-biased response, and finally allowing thus long-term parasite survival, proliferation and maturation. AE is fatal if not treated appropriately, but the current benzimidazole chemotherapy is far from optimal, and novel options for control are needed. Future research should focus on the elucidation of the crucial immunological events that lead to anergy in AE, and focus on providing a scientific basis for the development of novel and more effective immunotherapeutical options to support cure AE by abrogating anergy, anticipating also that a combination of immuno- and chemotherapy could provide a synergistic therapeutical effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Wang, Junhua and Gottstein, Bruno

Subjects:

600 Technology > 630 Agriculture

ISSN:

0141-9838

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

08 Jul 2016 11:43

Last Modified:

08 Jul 2016 11:43

Publisher DOI:

10.1111/pim.12292

PubMed ID:

26536823

Uncontrolled Keywords:

Echinococcus multilocularis; FGL2; TGF-β; Tregs alveolar echinococcosis immunotolerance

BORIS DOI:

10.7892/boris.82007

URI:

https://boris.unibe.ch/id/eprint/82007

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