Ethylene glycol poisoning in three dogs: Importance of early diagnosis and role of hemodialysis as a treatment option

Schweighauser, Ariane; Francey, Thierry (2016). Ethylene glycol poisoning in three dogs: Importance of early diagnosis and role of hemodialysis as a treatment option. Schweizer Archiv für Tierheilkunde, 158(2), pp. 109-114. Huber 10.17236/sat00051

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Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure. In addition to general supportive care, therapeutic interventions must include either antidotes blocking ADH-mediated metabolism or blood purification techniques to remove both the parent compound and the toxic metabolites. The goal of this case report is to describe three cases of acute antifreeze intoxication in dogs, and to discuss treatment options available for this poisoning.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine

UniBE Contributor:

Schweighauser, Ariane and Francey, Thierry

Subjects:

600 Technology > 630 Agriculture

ISSN:

0036-7281

Publisher:

Huber

Language:

English

Submitter:

Thierry Francey-Spicher

Date Deposited:

13 Mar 2017 13:48

Last Modified:

13 Mar 2017 13:51

Publisher DOI:

10.17236/sat00051

PubMed ID:

27145686

BORIS DOI:

10.7892/boris.82019

URI:

https://boris.unibe.ch/id/eprint/82019

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