In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives

Spicher, Martin; Röthlisberger, Carole; Lany, C.; Lundström-Stadelmann, Britta; Keiser, J.; Ortega-Mora, L. M.; Gottstein, Bruno; Hemphill, Andrew (2008). In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives. Antimicrobial agents and chemotherapy, 52(9), pp. 3447-3450. American Society for Microbiology 10.1128/AAC.00553-08

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In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg of body weight/day) had no effect. However, combination treatments of both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Spicher, Martin; Röthlisberger, Carole; Lundström Stadelmann, Britta; Gottstein, Bruno and Hemphill, Andrew

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

German

Submitter:

Britta Lundström Stadelmann

Date Deposited:

20 Jul 2017 16:27

Last Modified:

15 Jan 2019 09:18

Publisher DOI:

10.1128/AAC.00553-08

PubMed ID:

18625777

URI:

https://boris.unibe.ch/id/eprint/82055

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