Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite.

Bienz, Marianne; Dai, Wen Juan; Welle, Monika Maria; Gottstein, Bruno; Müller, Norbert (2003). Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite. Infection and immunity, 71(3), pp. 1569-1573. American Society for Microbiology 10.1128/IAI.71.3.1569-1573.2003

[img] Text
1569.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (189kB) | Request a copy

In the present study, interleukin-6 (IL-6)-deficient mice were infected with Giardia lamblia clone GS/M-83-H7. Murine IL-6 deficiency did not affect the synthesis of parasite-specific intestinal immunoglobulin A. However, in contrast to wild-type mice, IL-6-deficient animals were not able to control the acute phase of parasite infection. Reverse transcription-PCR-based quantitation of cytokine mRNA levels in peripheral lymph node cells exhibited a short-term up-regulation of IL-4 expression in IL-6-deficient mice that seemed to be associated with failure in controlling the parasite population. This observation suggests a further elucidation of IL-4-dependent, Th2-type regulatory processes regarding their potential to influence the course of G. lamblia infection in the experimental murine host.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Welle, Monika Maria; Gottstein, Bruno and Müller, Norbert

Subjects:

600 Technology > 630 Agriculture

ISSN:

0019-9567

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Norbert Müller

Date Deposited:

12 Jul 2016 08:12

Last Modified:

12 Jul 2016 08:12

Publisher DOI:

10.1128/IAI.71.3.1569-1573.2003

PubMed ID:

12595479

BORIS DOI:

10.7892/boris.82133

URI:

https://boris.unibe.ch/id/eprint/82133

Actions (login required)

Edit item Edit item
Provide Feedback