Cell Competition During Growth and Regeneration

Moreno, Eduardo; Gogna, Rajan; Shee, Kevin (2015). Cell Competition During Growth and Regeneration. Annual Review of Genetics, 49, pp. 697-718. Annual Reviews 10.1146/annurev-genet-112414-055214

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Tissue growth and regeneration are autonomous, stem-cell-mediated processes in which stem cells within the organ self-renew and differentiate to create new cells, leading to new tissue. The processes of growth and regeneration require communication and interplay between neighboring cells. In particular, cell competition, which is a process in which viable cells are actively eliminated by more competitive cells, has been increasingly implicated to play an important role. Here, we discuss the existing literature regarding the current landscape of cell competition, including classical pathways and models, fitness fingerprint mechanisms, and immune system mechanisms of cell competition. We further discuss the clinical relevance of cell competition in the physiological processes of tissue growth and regeneration, highlighting studies in clinically important disease models, including oncological, neurological, and cardiovascular diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Moreno, Eduardo and Gogna, Rajan

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0066-4197

Publisher:

Annual Reviews

Language:

English

Submitter:

Eduardo Moreno

Date Deposited:

01 Jun 2016 14:47

Last Modified:

02 Jun 2016 10:56

Publisher DOI:

10.1146/annurev-genet-112414-055214

PubMed ID:

26631518

BORIS DOI:

10.7892/boris.82412

URI:

https://boris.unibe.ch/id/eprint/82412

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