Karousis, Evangelos; Nasif, Sofia; Mühlemann, Oliver (2016). Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact. Wiley Interdisciplinary Reviews: RNA, 7(5), pp. 661-682. Wiley 10.1002/wrna.1357
|
Text
wrna1357-final.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (1MB) | Preview |
Nonsense-mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a premature termination codon. Meanwhile, it became clear that NMD has a much broader impact on gene expression and additional biological functions beyond quality control are continuously being discovered. We review here the current views regarding the molecular mechanisms of NMD, according to which NMD ensues on mRNAs that fail to terminate translation properly, and point out the gaps in our understanding. We further summarize the recent literature on an ever-rising spectrum of biological processes in which NMD appears to be involved, including homeostatic control of gene expression, development and differentiation, as well as viral defense.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Karousis, Evangelos, Nasif, Sofia, Mühlemann, Oliver |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1757-7004 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Christina Schüpbach |
Date Deposited: |
12 Jul 2016 12:09 |
Last Modified: |
05 Dec 2022 14:56 |
Publisher DOI: |
10.1002/wrna.1357 |
BORIS DOI: |
10.7892/boris.82540 |
URI: |
https://boris.unibe.ch/id/eprint/82540 |
Actions (login required)
 |
Edit item |