Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

Karousis, Evangelos; Nasif, Sofia; Mühlemann, Oliver (2016). Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact. Wiley Interdisciplinary Reviews: RNA, 7(5), pp. 661-682. Wiley 10.1002/wrna.1357

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Nonsense-mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a premature termination codon. Meanwhile, it became clear that NMD has a much broader impact on gene expression and additional biological functions beyond quality control are continuously being discovered. We review here the current views regarding the molecular mechanisms of NMD, according to which NMD ensues on mRNAs that fail to terminate translation properly, and point out the gaps in our understanding. We further summarize the recent literature on an ever-rising spectrum of biological processes in which NMD appears to be involved, including homeostatic control of gene expression, development and differentiation, as well as viral defense.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Karousis, Evangelos; Nasif, Sofia and Mühlemann, Oliver

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1757-7004

Publisher:

Wiley

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

12 Jul 2016 12:09

Last Modified:

28 Aug 2016 02:04

Publisher DOI:

10.1002/wrna.1357

BORIS DOI:

10.7892/boris.82540

URI:

https://boris.unibe.ch/id/eprint/82540

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