No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy

Ortiz, Millán; Poloni, Estella S; Furrer, Hansjakob; Kovari, Helen; Martinez, Raquel; Arnedo, Mireia; Elzi, Luigia; Bernasconi, Enos; Vernazza, Pietro; Hirschel, Bernard; Cavassini, Matthias; Ledergerber, Bruno; Günthard, Huldrych F; Telenti, Amalio; Tarr, Philip E; Swiss HIV Cohort Study, (2011). No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy. Journal of infectious diseases, 203(5), pp. 620-4. Cary, N.C.: Oxford University Press 10.1093/infdis/jiq106

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The potential for mitochondrial (mt) DNA mutation accumulation during antiretroviral therapy (ART), and preferential accumulation in patients with lipoatrophy compared with control participants, remains controversial. We sequenced the entire mitochondrial genome, both before ART and after ART exposure, in 29 human immunodeficiency virus (HIV)-infected Swiss HIV Cohort Study participants initiating a first-line thymidine analogue-containing ART regimen. No accumulation of mtDNA mutations or deletions was detected in 13 participants who developed lipoatrophy or in 16 control participants after significant and comparable ART exposure (median duration, 3.3 and 3.7 years, respectively). In HIV-infected persons, the development of lipoatrophy is unlikely to be associated with accumulation of mtDNA mutations detectable in peripheral blood.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Furrer, Hansjakob

ISSN:

0022-1899

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

27 Apr 2018 08:47

Publisher DOI:

10.1093/infdis/jiq106

PubMed ID:

21227914

Web of Science ID:

000287028000008

BORIS DOI:

10.7892/boris.8260

URI:

https://boris.unibe.ch/id/eprint/8260 (FactScience: 213776)

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