Disturbances of agency and ownership in schizophrenia: An auditory verbal event related potentials study

Bühler, T; Kindler, J; Schneider, RC; Strik, Werner; Dierks, Thomas; Hubl, Daniela; König, Thomas (2016). Disturbances of agency and ownership in schizophrenia: An auditory verbal event related potentials study. Brain topography, 29(5), pp. 716-727. Springer 10.1007/s10548-016-0495-1

[img] Text
art%3A10.1007%2Fs10548-016-0495-1.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

A ‘sense of self’ is essentially the ability to distinguish between self-generated and external stimuli. It consists of at least two very basic senses: a sense of agency and a sense of ownership. Disturbances seem to provide a basic deficit in many psychiatric diseases. The aim of our study was to manipulate those qualities separately in 28 patients with schizophrenia (14 auditory hallucinators and 14 non-hallucinators) and 28 healthy controls (HC) and to investigate the effects on the topographies and the power of the event-related potential (ERP). We performed a 76-channel EEG while the participants performed the task as in our previous paper. We computed ERPs and difference maps for the conditions and compared the amount of agency and ownership between the HC and the patients. Furthermore, we compared the global field power and the topographies of these effects. Our data showed effects of agency and ownership in the healthy controls and the hallucinator group and to a lesser degree in the non-hallucinator group. We found a reduction of the N100 during the presence of agency, and a bilateral temporal negativity related to the presence of ownership. For the agency effects, we found significant differences between HC and the patients. Contrary to the expectations, our findings were more pronounced in non-hallucinators, suggesting a more profoundly disturbed sense of agency compared to hallucinators. A contemporary increase of global field power in both patient groups indicates a compensatory recruitment of other mechanisms not normally associated with the processing of agency and ownership.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Kindler, Jochen; Strik, Werner; Dierks, Thomas; Hubl, Daniela and König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0896-0267

Publisher:

Springer

Language:

English

Submitter:

Fabienne Bolliger

Date Deposited:

02 Aug 2016 10:55

Last Modified:

04 Jan 2017 11:27

Publisher DOI:

10.1007/s10548-016-0495-1

PubMed ID:

27209172

BORIS DOI:

10.7892/boris.82672

URI:

https://boris.unibe.ch/id/eprint/82672

Actions (login required)

Edit item Edit item
Provide Feedback