Association of the (CA)n repeat polymorphism of insulin-like growth factor-I and -202 A/C IGF-binding protein-3 promoter polymorphism with adult height in patients with severe growth hormone deficiency

Miletta, Maria Consolata; Scheidegger, Ursina A; Giordano, Mara; Bozzola, Mauro; Pagani, Sara; Bona, Gianni; Dattani, Mehul; Hindmarsh, Peter C; Petkovic, Vibor; Oser-Meier, Monika; Flück, Christa E; Mullis, Primus-E (2012). Association of the (CA)n repeat polymorphism of insulin-like growth factor-I and -202 A/C IGF-binding protein-3 promoter polymorphism with adult height in patients with severe growth hormone deficiency. Clinical endocrinology, 76(5), pp. 683-90. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2265.2011.04267.x

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A number of mathematical models for predicting growth and final height outcome have been proposed to enable the clinician to 'individualize' growth-promoting treatment. However, despite optimizing these models, many patients with isolated growth hormone deficiency (IGHD) do not reach their target height. The aim of this study was to analyse the impact of polymorphic genotypes [CA repeat promoter polymorphism of insulin-like growth factor-I (IGF-I) and the -202 A/C promoter polymorphism of IGF-Binding Protein-3 (IGFBP-3)] on variable growth factors as well as final height in severe IGHD following GH treatment. DESIGN, PATIENTS AND CONTROLS: One hundred seventy eight (IGF-I) and 167 (IGFBP-3) subjects with severe growth retardation because of IGHD were studied. In addition, the various genotypes were also studied in a healthy control group of 211 subjects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Miletta, Maria Consolata; Scheidegger, Ursina; Petkovic, Vibor; Oser-Meier, Monika; Flück, Christa and Mullis, Primus-Eugen

ISSN:

0300-0664

ISBN:

0300-0664

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

06 Dec 2013 13:29

Publisher DOI:

10.1111/j.1365-2265.2011.04267.x

PubMed ID:

22026507

Web of Science ID:

000302531200011

Additional Information:

Miletta, Maria Consolata Scheidegger, Ursina A. Giordano, Mara Bozzola, Mauro Pagani, Sara Bona, Gianni Dattani, Mehul Hindmarsh, Peter C. Petkovic, Vibor Oser-Meier, Monika Flueck, Christa E. Mullis, Primus-E.

URI:

https://boris.unibe.ch/id/eprint/8315 (FactScience: 213834)

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