Changes in Scleral Architecture in Chronic Vogt-Koyanagi-Harada Disease.

Harada, Y; Bhat, P; Munk, Marion; Goldstein, DA (2017). Changes in Scleral Architecture in Chronic Vogt-Koyanagi-Harada Disease. Ocular immunology and inflammation, 25(1), pp. 85-92. Informa Healthcare 10.3109/09273948.2015.1057600

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PURPOSE: To describe scleral changes in chronic VKH. METHODS: Medical records of patients with chronic VKH were retrospectively reviewed. Change of scleral architecture was defined as progressive posterior bowing on OCT, axial length elongation, and/or increased myopia more than -1.0 D, not explicable by other etiologies. RESULTS: In total, 28 eyes (16 patients) with mean age of disease onset 32.5 ± 14.0 years were included in the study. Disease duration was 15.1 ± 10.2 years. Eight eyes (28.6%) showed progressive scleral architectural changes. Five eyes (18%) developed scleral changes on OCT, not seen on prior imaging (2-12 years earlier). One eye had posterior bowing on OCT with increased axial length, both eyes of a bilateral pseudophake developed increased myopia with increased axial length. Well-circumscribed chorioretinal atrophy within the arcade was associated with progressive scleral change. CONCLUSIONS: Progressive scleral change may develop as a late complication of VKH. The association with well-circumscribed chorioretinal atrophy suggests that chronic choroidal inflammation may be responsible.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Munk, Marion


600 Technology > 610 Medicine & health




Informa Healthcare




Marion Munk

Date Deposited:

28 Jun 2016 09:59

Last Modified:

27 Feb 2018 13:11

Publisher DOI:


PubMed ID:



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