Influence of the vitreomacular interface on the efficacy of intravitreal therapy for uveitis-associated cystoid macular oedema.

Munk, Marion; Ram, Radha; Rademaker, Alfred; Liu, Dachao; Setlur, Vikram; Chau, Felix; Schmidt-Erfurth, Ursula; Goldstein, Debra A (2015). Influence of the vitreomacular interface on the efficacy of intravitreal therapy for uveitis-associated cystoid macular oedema. Acta ophthalmologica, 93(7), e561-e567. Blackwell Munksgaard 10.1111/aos.12699

[img] Text
Munk_et_al-2015-Acta_Ophthalmologica.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (343kB) | Request a copy

PURPOSE To evaluate the effect of the vitreomacular interface (VMI) on treatment efficacy of intravitreal therapy in uveitic cystoid macular oedema (CME). METHODS Retrospective analysis of CME resolution, CME recurrence rate and monthly course of central retinal thickness (CRT), retinal volume (RV) and best corrected visual acuity (BCVA) after intravitreal injection with respect to the VMI configuration on spectral-domain OCT using chi-squared test and repeated measures anova adjusted for confounding covariates epiretinal membrane, administered drug and subretinal fluid. RESULTS Fifty-nine eyes of 53 patients (mean age: 47.4 ± 16.9 years) were included. VMI status had no effect on complete CME resolution rate (p = 0.16, corrected p-value: 0.32), time until resolution (p = 0.09, corrected p-value: 0.27) or CME relapse rate (p = 0.29, corrected p-value: 0.29). Change over time did not differ among the VMI configuration groups for BVCA (p = 0.82) and RV (p = 0.18), but CRT decrease was greater and faster in the posterior vitreous detachment (PVD) group compared to the posterior vitreous attachment (PVA) and vitreous macular adhesion (VMA) groups (p = 0.04). Also, the percentage of patients experiencing a ≥ 20% CRT thickness decrease after intravitreal injection was greater in the PVD group (83%) compared to the VMA (64%) and the PVA (16%) group (p = 0.027), however, not after correction for multiple testing (corrected p-value: 0.11). CONCLUSION The VMI configuration seems to be a factor contributing to treatment efficacy in uveitic CME in terms of CRT decrease, although BCVA outcome did not differ according to VMI status.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1755-375X

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Marion Munk

Date Deposited:

28 Jun 2016 10:21

Last Modified:

28 Jun 2016 10:21

Publisher DOI:

10.1111/aos.12699

PubMed ID:

25708777

Uncontrolled Keywords:

cystoid macular oedema; intravitreal therapy; macular oedema; optical coherence tomography; posterior vitreous attachment; triamcinolone; uveitis; vitreomacular adhesion; vitreomacular traction

BORIS DOI:

10.7892/boris.83441

URI:

https://boris.unibe.ch/id/eprint/83441

Actions (login required)

Edit item Edit item
Provide Feedback