Enhanced depth imaging optical coherence tomography of congenital cavitary optic disc anomaly (CODA).

Munk, Marion; Simjanoski, Evica; Fingert, John H; Jampol, Lee M (2015). Enhanced depth imaging optical coherence tomography of congenital cavitary optic disc anomaly (CODA). British journal of ophthalmology, 99(4), pp. 549-555. BMJ Publishing Group 10.1136/bjophthalmol-2014-305722

[img] Text
549.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (11MB) | Request a copy

AIM To report the finding of extension of the 4th hyper-reflective band and retinal tissue into the optic disc in patients with cavitary optic disc anomalies (CODAs). METHODS In this observational study, 10 patients (18 eyes) with sporadic or autosomal dominant CODA were evaluated with enhanced depth imaging optical coherence tomography (EDI-OCT) and colour fundus images for the presence of 4th hyper-reflective band extension into the optic disc. RESULTS Of 10 CODA patients (18 eyes), five patients (8 eyes) showed a definite 4th hyper-reflective band (presumed retinal pigment epithelium (RPE)) extension into the optic disc. In these five patients (seven eyes), the inner retinal layers also extended with the 4th hyper-reflective band into the optic disc. Best corrected visual acuity ranged from 20/20 to 20/200. In three patients (four eyes), retinal splitting/schisis was present and in two patients (two eyes), the macula was involved. In all cases, the 4th hyper-reflective band extended far beyond the termination of the choroid into the optic disc. The RPE extension was found either temporally or nasally in areas of optic nerve head excavation, most often adjacent to peripapillary pigment. Compared with eyes without RPE extension, eyes with RPE extension were more myopic (mean dioptres -0.9±2.6 vs -8.8±5, p=0.043). CONCLUSIONS The RPE usually stops near the optic nerve border separated by a border tissue. With CODA, extension of this hyper-reflective band and retinal tissue into the disc is possible and best evaluable using EDI-OCT or analogous image modalities. Whether this is a finding specific for CODA, linked to specific gene loci or is also seen in patients with other optic disc abnormalities needs further evaluation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-1161

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Marion Munk

Date Deposited:

28 Jun 2016 11:15

Last Modified:

28 Jun 2016 11:15

Publisher DOI:

10.1136/bjophthalmol-2014-305722

PubMed ID:

25359902

Uncontrolled Keywords:

Imaging; Optic Nerve

BORIS DOI:

10.7892/boris.83443

URI:

https://boris.unibe.ch/id/eprint/83443

Actions (login required)

Edit item Edit item
Provide Feedback