Munk, Marion; Beck, Marco; Kolb, Simone; Larsen, Michael; Hamann, Steffen; Valmaggia, Christophe; Zinkernagel, Martin (2017). Quantification of retinal layer thickness changes in acute macular neuroretinopathy. British journal of ophthalmology, 101(2), pp. 160-165. BMJ Publishing Group 10.1136/bjophthalmol-2016-308367
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PURPOSE
To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN).
METHODS
AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up.
RESULTS
Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 µm vs 73±17 µm, p=0.002). The other layers, including inner nuclear layer (37±8 µm vs 38±6 µm, p=0.9) and outer plexiform layer (OPL) (45±19 µm vs 33±16 µm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 µm vs fellow eye: 39±16 µm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 µm vs fellow eye: 69±16 µm, p=0.002).
CONCLUSIONS
AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology 04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine |
UniBE Contributor: |
Munk, Marion, Kolb, Simone, Zinkernagel, Martin Sebastian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0007-1161 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Marion Munk |
Date Deposited: |
29 Jul 2016 14:30 |
Last Modified: |
02 Mar 2023 23:27 |
Publisher DOI: |
10.1136/bjophthalmol-2016-308367 |
PubMed ID: |
27170518 |
Uncontrolled Keywords: |
Imaging; Macula |
BORIS DOI: |
10.7892/boris.83449 |
URI: |
https://boris.unibe.ch/id/eprint/83449 |
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