Quantification of retinal layer thickness changes in acute macular neuroretinopathy.

Munk, Marion; Beck, Marco; Kolb, Simone; Larsen, Michael; Hamann, Steffen; Valmaggia, Christophe; Zinkernagel, Martin (2017). Quantification of retinal layer thickness changes in acute macular neuroretinopathy. British journal of ophthalmology, 101(2), pp. 160-165. BMJ Publishing Group 10.1136/bjophthalmol-2016-308367

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PURPOSE To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN). METHODS AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up. RESULTS Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 µm vs 73±17 µm, p=0.002). The other layers, including inner nuclear layer (37±8 µm vs 38±6 µm, p=0.9) and outer plexiform layer (OPL) (45±19 µm vs 33±16 µm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 µm vs fellow eye: 39±16 µm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 µm vs fellow eye: 69±16 µm, p=0.002). CONCLUSIONS AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Munk, Marion; Kolb, Simone and Zinkernagel, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-1161

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Marion Munk

Date Deposited:

29 Jul 2016 14:30

Last Modified:

25 Oct 2019 15:56

Publisher DOI:

10.1136/bjophthalmol-2016-308367

PubMed ID:

27170518

Uncontrolled Keywords:

Imaging; Macula

BORIS DOI:

10.7892/boris.83449

URI:

https://boris.unibe.ch/id/eprint/83449

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