Gesture performance in first- and multiple-episode patients with schizophrenia spectrum disorders

Stegmayer, Katharina; Moor, Jeanne Yvonne; Vanbellingen, Tim; Bohlhalter, Stephan; Müri, René Martin; Strik, Werner; Walther, Sebastian (2016). Gesture performance in first- and multiple-episode patients with schizophrenia spectrum disorders. Neuropsychobiology, 73(4), pp. 201-208. Karger 10.1159/000446116

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BACKGROUND/AIM Gesturing plays an important role in social behavior and social learning. Deficits are frequent in schizophrenia and may contribute to impaired social functioning. Information about deficits during the course of the disease and presence of severity and patterns of impairment in first-episode patients is missing. Hence, we aimed to investigate gesturing in first- compared to multiple-episode schizophrenia patients and healthy controls. METHODS In 14 first-episode patients, 14 multiple-episode patients and 16 healthy controls matched for age, gender and education, gesturing was assessed by the comprehensive Test of Upper Limb Apraxia. Performance in two domains of gesturing - imitation and pantomime - was recorded on video. Raters of gesture performance were blinded. RESULTS Patients with multiple episodes had severe gestural deficits. For almost all gesture categories, performance was worse in multiple- than in first-episode patients. First-episode patients demonstrated subtle deficits with a comparable pattern. CONCLUSIONS Subjects with multiple psychotic episodes have severe deficits in gesturing, while only mild impairments were found in first-episode patients independent of age, gender, education and negative symptoms. The results indicate that gesturing is impaired at the onset of disease and likely to further deteriorate during its course.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > University Psychiatric Services

UniBE Contributor:

Stegmayer, Katharina; Moor, Jeanne Yvonne; Vanbellingen, Tim; Bohlhalter, Stephan; Müri, René Martin; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0302-282X

Publisher:

Karger

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

13 Jul 2016 15:41

Last Modified:

26 Jun 2017 13:55

Publisher DOI:

10.1159/000446116

PubMed ID:

27229523

BORIS DOI:

10.7892/boris.83458

URI:

https://boris.unibe.ch/id/eprint/83458

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