M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis

Schlapbach, Luregn J; Kjaer, Troels R; Thiel, Steffen; Mattmann, Maika; Nelle, Mathias; Wagner, Bendicht P; Ammann, Roland A; Aebi, Christoph; Jensenius, Jens C (2012). M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis. Pediatric research, 71(4 Pt 1), pp. 368-74. New York, N.Y.: Nature Publishing Group 10.1038/pr.2011.71

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The pattern-recognition molecule M-ficolin is synthesized by monocytes and neutrophils. M-ficolin activates the complement system in a manner similar to mannan-binding lectin (MBL), but little is known about its role in host defense. Neonates are highly vulnerable to bacterial sepsis, in particular, due to their decreased phagocytic function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Schlapbach, Luregn Jan; Nelle, Mathias; Wagner, Bendicht Peter; Ammann, Roland and Aebi, Christoph

ISSN:

0031-3998

ISBN:

0031-3998

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

17 Mar 2015 21:04

Publisher DOI:

10.1038/pr.2011.71

PubMed ID:

22391637

Web of Science ID:

000301884500008

Additional Information:

Schlapbach, Luregn J. Kjaer, Troels R. Thiel, Steffen Mattmann, Maika Nelle, Mathias Wagner, Bendicht P. Ammann, Roland A. Aebi, Christoph Jensenius, Jens C.;1

URI:

https://boris.unibe.ch/id/eprint/8346 (FactScience: 213872)

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