Rhinovirus Infections and Associated Respiratory Morbidity in Infants: A Prospective Cohort Study.

Mack, Ines; Kieninger, Elisabeth; Cangiano, Giulia; Tapparel, Caroline; Kuehni, Claudia; Spycher, Ben; Kaiser, Laurent; Frey, Urs; Regamey, Nicolas; Latzin, Philipp (2016). Rhinovirus Infections and Associated Respiratory Morbidity in Infants: A Prospective Cohort Study. Pediatric infectious disease journal, 35(10), pp. 1069-74. Lippincott Williams & Wilkins 10.1097/INF.0000000000001240

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BACKGROUND

Risk factors promoting rhinovirus (RV) infections are inadequately described in healthy populations, especially infants.

OBJECTIVES

To determine the frequency of symptomatic and asymptomatic RV infections and identify possible risk factors from host and environment among otherwise healthy infants.

METHODS

In a prospective birth cohort, respiratory health was assessed in 41 term-born infants by weekly telephone interviews during the first year of life, and weekly nasal swabs were collected to determine RV prevalence. In a multilevel logistic regression model, associations between prevalence and respiratory symptoms during RV infections and host/environmental factors were determined.

RESULTS

27% of nasal swabs in 41 infants tested positive for RVs. Risk factors for RV prevalence were autumn months (OR=1.71, p=0.01, 95% CI 1.13-2.61), outdoor temperatures between 5-10 °C (OR=2.33, p=0.001, 95% CI 1.41-3.86), older siblings (OR=2.60, p=0.001, 95% CI 1.50-4.51) and childcare attendance (OR=1.53, p=0.07, 95% CI 0.96-2.44). 51% of RV-positive samples were asymptomatic. Respiratory symptoms during RV infections were less likely during the first three months of life (OR=0.34, p=0.003, 95% CI 0.17-0.69) and in infants with atopic mothers (OR=0.44, p=0.008, 95% CI 0.24-0.80). Increased tidal volume (OR=1.67, p=0.03, 95% CI 1.04-2.68) and outdoor temperatures between 2-5 °C (OR=2.79, p=0.02, 95% CI 1.17-6.61) were associated with more symptoms.

CONCLUSIONS

RVs are highly prevalent during the first year of life, and most infections are asymptomatic. Frequency of RV infections is associated with environmental factors, while respiratory symptoms during RV infections are linked to host determinants like infant age, maternal atopy, or premorbid lung function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Mack, Ines, Kieninger, Elisabeth, Kühni, Claudia, Spycher, Ben, Regamey, Nicolas, Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0891-3668

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

07 Jun 2016 11:55

Last Modified:

05 Dec 2022 14:56

Publisher DOI:

10.1097/INF.0000000000001240

PubMed ID:

27254029

BORIS DOI:

10.7892/boris.83594

URI:

https://boris.unibe.ch/id/eprint/83594

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