PICADAR: a diagnostic predictive tool for primary ciliary dyskinesia.

Behan, Laura; Dimitrov, Borislav D; Kuehni, Claudia E; Hogg, Claire; Carroll, Mary; Evans, Hazel J; Goutaki, Myrofora; Harris, Amanda; Packham, Samantha; Walker, Woolf T; Lucas, Jane S (2016). PICADAR: a diagnostic predictive tool for primary ciliary dyskinesia. European respiratory journal, 47(4), pp. 1103-1112. European Respiratory Society 10.1183/13993003.01551-2015

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Symptoms of primary ciliary dyskinesia (PCD) are nonspecific and guidance on whom to refer for testing is limited. Diagnostic tests for PCD are highly specialised, requiring expensive equipment and experienced PCD scientists. This study aims to develop a practical clinical diagnostic tool to identify patients requiring testing.Patients consecutively referred for testing were studied. Information readily obtained from patient history was correlated with diagnostic outcome. Using logistic regression, the predictive performance of the best model was tested by receiver operating characteristic curve analyses. The model was simplified into a practical tool (PICADAR) and externally validated in a second diagnostic centre.Of 641 referrals with a definitive diagnostic outcome, 75 (12%) were positive. PICADAR applies to patients with persistent wet cough and has seven predictive parameters: full-term gestation, neonatal chest symptoms, neonatal intensive care admittance, chronic rhinitis, ear symptoms, situs inversus and congenital cardiac defect. Sensitivity and specificity of the tool were 0.90 and 0.75 for a cut-off score of 5 points. Area under the curve for the internally and externally validated tool was 0.91 and 0.87, respectively.PICADAR represents a simple diagnostic clinical prediction rule with good accuracy and validity, ready for testing in respiratory centres referring to PCD centres.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Kühni, Claudia and Goutaki, Myrofora

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0903-1936

Publisher:

European Respiratory Society

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

07 Jun 2016 13:49

Last Modified:

09 Jun 2016 12:14

Publisher DOI:

10.1183/13993003.01551-2015

PubMed ID:

26917608

BORIS DOI:

10.7892/boris.83618

URI:

https://boris.unibe.ch/id/eprint/83618

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