Staempfli, Roger; Schmid, Jean-Paul; Schenker, Stephan; Eser, Prisca; Trachsel, Lukas; Deluigi, Christina; Wustmann, Kerstin Brigitte; Thomet, Corina; Greutmann, Matthias; Tobler, Daniel; Stambach, Dominik; Wilhelm, Matthias; Schwerzmann, Markus (2016). Cardiopulmonary adaptation to short-term high altitude exposure in adult Fontan patients. Heart, 102(16), pp. 1296-1301. BMJ Publishing Group 10.1136/heartjnl-2016-309682
Text
Heart-2016-Staempfli-heartjnl-2016-309682.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (446kB) |
OBJECTIVE
High altitude-related hypoxia induces pulmonary vasoconstriction. In Fontan patients without a contractile subpulmonary ventricle, an increase in pulmonary artery pressure is expected to decrease circulatory output and reduce exercise capacity. This study investigates the direct effects of short-term high altitude exposure on pulmonary blood flow (PBF) and exercise capacity in Fontan patients.
METHODS
16 adult Fontan patients (mean age 28±7 years, 56% female) and 14 matched controls underwent cardiopulmonary exercise testing with measurement of PBF with a gas rebreathing system at 540 m (low altitude) and at 3454 m (high altitude) within 12 weeks.
RESULTS
PBF at rest and at exercise was higher in controls than in Fontan patients, both at low and high altitude. PBF increased twofold in Fontan patients and 2.8-fold in the control group during submaximal exercise, with no significant difference between low and high altitude (p=0.290). A reduction in peak oxygen uptake at high compared with low altitude was observed in Fontan patients (22.8±5.1 and 20.5±3.8 mL/min/kg, p<0.001) and the control group (35.0±7.4 and 29.1±6.5 mL/min/kg, p<0.001). The reduction in exercise capacity was less pronounced in Fontan patients compared with controls (9±12% vs 17±8%, p=0.005). No major adverse clinical event was observed.
CONCLUSIONS
Short-term high altitude exposure has no negative impact on PBF and exercise capacity in Fontan patients when compared with controls, and was clinically well tolerated.
TRIAL REGISTRATION NUMBER
NCT02237274: Results.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Eser, Prisca Christina, Trachsel, Lukas Daniel, Deluigi, Christina, Wustmann, Kerstin Brigitte, Wilhelm, Matthias, Schwerzmann, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1355-6037 |
Publisher: |
BMJ Publishing Group |
Funders: |
[83] Mach-Gaenslen Foundation |
Language: |
English |
Submitter: |
Markus Schwerzmann |
Date Deposited: |
18 Jul 2016 14:34 |
Last Modified: |
02 Mar 2023 23:27 |
Publisher DOI: |
10.1136/heartjnl-2016-309682 |
PubMed ID: |
27217067 |
BORIS DOI: |
10.7892/boris.83627 |
URI: |
https://boris.unibe.ch/id/eprint/83627 |