Cardiopulmonary adaptation to short-term high altitude exposure in adult Fontan patients

Staempfli, Roger; Schmid, Jean-Paul; Schenker, Stephan; Eser, Prisca; Trachsel, Lukas; Deluigi, Christina; Wustmann, Kerstin Brigitte; Thomet, Corina; Greutmann, Matthias; Tobler, Daniel; Stambach, Dominik; Wilhelm, Matthias; Schwerzmann, Markus (2016). Cardiopulmonary adaptation to short-term high altitude exposure in adult Fontan patients. Heart, 102(16), pp. 1296-1301. BMJ Publishing Group 10.1136/heartjnl-2016-309682

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OBJECTIVE High altitude-related hypoxia induces pulmonary vasoconstriction. In Fontan patients without a contractile subpulmonary ventricle, an increase in pulmonary artery pressure is expected to decrease circulatory output and reduce exercise capacity. This study investigates the direct effects of short-term high altitude exposure on pulmonary blood flow (PBF) and exercise capacity in Fontan patients. METHODS 16 adult Fontan patients (mean age 28±7 years, 56% female) and 14 matched controls underwent cardiopulmonary exercise testing with measurement of PBF with a gas rebreathing system at 540 m (low altitude) and at 3454 m (high altitude) within 12 weeks. RESULTS PBF at rest and at exercise was higher in controls than in Fontan patients, both at low and high altitude. PBF increased twofold in Fontan patients and 2.8-fold in the control group during submaximal exercise, with no significant difference between low and high altitude (p=0.290). A reduction in peak oxygen uptake at high compared with low altitude was observed in Fontan patients (22.8±5.1 and 20.5±3.8 mL/min/kg, p<0.001) and the control group (35.0±7.4 and 29.1±6.5 mL/min/kg, p<0.001). The reduction in exercise capacity was less pronounced in Fontan patients compared with controls (9±12% vs 17±8%, p=0.005). No major adverse clinical event was observed. CONCLUSIONS Short-term high altitude exposure has no negative impact on PBF and exercise capacity in Fontan patients when compared with controls, and was clinically well tolerated. TRIAL REGISTRATION NUMBER NCT02237274: Results.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Eser, Prisca; Trachsel, Lukas; Deluigi, Christina; Wustmann, Kerstin Brigitte; Wilhelm, Matthias and Schwerzmann, Markus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1355-6037

Publisher:

BMJ Publishing Group

Funders:

[83] Mach-Gaenslen Foundation

Language:

English

Submitter:

Markus Schwerzmann

Date Deposited:

18 Jul 2016 14:34

Last Modified:

29 Jul 2016 01:31

Publisher DOI:

10.1136/heartjnl-2016-309682

PubMed ID:

27217067

BORIS DOI:

10.7892/boris.83627

URI:

https://boris.unibe.ch/id/eprint/83627

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