Epileptic networks are strongly connected with and without the effects of interictal discharges

Iannotti, Giannina R; Grouiller, Frédéric; Centeno, Maria; Carmichael, David W; Abela, Eugenio; Wiest, Roland; Korff, Christian; Seeck, Margitta; Michel, Christoph; Pittau, Francesca; Vulliemoz, Serge (2016). Epileptic networks are strongly connected with and without the effects of interictal discharges. Epilepsia, 57(7), pp. 1086-1096. Wiley-Blackwell 10.1111/epi.13400

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OBJECTIVE Epilepsy is increasingly considered as the dysfunction of a pathologic neuronal network (epileptic network) rather than a single focal source. We aimed to assess the interactions between the regions that comprise the epileptic network and to investigate their dependence on the occurrence of interictal epileptiform discharges (IEDs). METHODS We analyzed resting state simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) recordings in 10 patients with drug-resistant focal epilepsy with multifocal IED-related blood oxygen level-dependent (BOLD) responses and a maximum t-value in the IED field. We computed functional connectivity (FC) maps of the epileptic network using two types of seed: (1) a 10-mm diameter sphere centered in the global maximum of IED-related BOLD map, and (2) the independent component with highest correlation to the IED-related BOLD map, named epileptic component. For both approaches, we compared FC maps before and after regressing out the effect of IEDs in terms of maximum and mean t-values and percentage of map overlap. RESULTS Maximum and mean FC maps t-values were significantly lower after regressing out IEDs at the group level (p < 0.01). Overlap extent was 85% ± 12% and 87% ± 12% when the seed was the 10-mm diameter sphere and the epileptic component, respectively. SIGNIFICANCE Regions involved in a specific epileptic network show coherent BOLD fluctuations independent of scalp EEG IEDs. FC topography and strength is largely preserved by removing the IED effect. This could represent a signature of a sustained pathologic network with contribution from epileptic activity invisible to the scalp EEG.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Abela, Eugenio and Wiest, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0013-9580

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

19 Jul 2016 09:47

Last Modified:

19 Jul 2016 09:47

Publisher DOI:

10.1111/epi.13400

PubMed ID:

27153929

Uncontrolled Keywords:

EEG-fMRI; Epilepsy; Functional connectivity; IED; Independent component analysis

BORIS DOI:

10.7892/boris.83714

URI:

https://boris.unibe.ch/id/eprint/83714

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