Susac's syndrome: Leptomeningeal enhancement on 3D FLAIR MRI

Engisch, Renate; Titelbaum, David S; Chilver-Stainer, Lara; Kellner-Weldon, Frauke (2016). Susac's syndrome: Leptomeningeal enhancement on 3D FLAIR MRI. Multiple sclerosis journal, 22(7), pp. 972-974. Sage 10.1177/1352458516636836

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BACKGROUND Contrast-enhanced (ce) fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) has recently been shown to identify leptomeningeal pathology in multiple sclerosis. OBJECTIVE To demonstrate leptomeningeal enhancement on three-dimensional (3D) FLAIR in a case of Susac's syndrome. METHODS Leptomeningeal enhancement was correlated with clinical activity over 20 months and compared to retinal fluorescein angiography. RESULTS The size, number, and location of leptomeningeal enhancement varied over time and generally correlated with symptom severity. The appearance was remarkably similar to that of retinal vasculopathy. CONCLUSION Ce 3D FLAIR may aid in diagnosis and understanding of pathophysiology in Susac's syndrome and may serve as a biomarker for disease activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Engisch, Renate; Chilver-Stainer, Lara and Kellner-Weldon, Frauke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1352-4585

Publisher:

Sage

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

18 Jul 2016 16:40

Last Modified:

18 Jul 2016 16:40

Publisher DOI:

10.1177/1352458516636836

PubMed ID:

27207452

Uncontrolled Keywords:

Susac’s syndrome; contrast-enhanced FLAIR; leptomeningeal pathology

URI:

https://boris.unibe.ch/id/eprint/83715

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