Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms - A Randomized, Placebo Controlled Cross-Over Study

Hoffmann, A; Klein, Sabine; Gründemann, C; Garcia-Käufer, M; Wolf, Ursula; Huber, R (2016). Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms - A Randomized, Placebo Controlled Cross-Over Study. Phytotherapy research, 30(9), pp. 1481-1486. Wiley 10.1002/ptr.5649

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Nasal spray from lemon and quince (LQNS) is used to treat hay fever symptoms and has been shown to inhibit histamine release from mast cells in vitro. Forty-three patients with grass pollen allergy (GPA) were randomized to be treated either with placebo or LQNS for one week, respectively, in a cross-over study. At baseline and after the respective treatments patients were provoked with grass pollen allergen. Outcome parameters were nasal flow measured with rhinomanometry (primary), a nasal symptom score, histamine in the nasal mucus and tolerability. In the per protocol population absolute inspiratory nasal flow 10 and 20 min after provocation was higher with LQNS compared to placebo (-37 ± 87 mL/s; p = 0.027 and -44 ± 85 mL/s; p = 0.022). The nasal symptom score showed a trend (3.3 ± 1.8 in the placebo and 2.8 ± 1.5 in the LQNS group; p = 0.070) in favor of LQNS; the histamine concentration was not significantly different between the groups. Tolerability of both, LQNS and placebo, was rated as very good. LQNS seems to have an anti-allergic effect in patients with GPA. Copyright © 2016 John Wiley & Sons, Ltd.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of Complementary Medicine (ICOM)

UniBE Contributor:

Klein, Sabine and Wolf, Ursula

Subjects:

500 Science > 580 Plants (Botany)
600 Technology > 610 Medicine & health

ISSN:

1099-1573

Publisher:

Wiley

Language:

English

Submitter:

Sabine Klein

Date Deposited:

19 Jul 2016 09:51

Last Modified:

06 Sep 2016 01:31

Publisher DOI:

10.1002/ptr.5649

PubMed ID:

27282490

Uncontrolled Keywords:

allergy; anthroposophic medicine; grass pollen; lemon; quince

BORIS DOI:

10.7892/boris.83725

URI:

https://boris.unibe.ch/id/eprint/83725

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