Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva

Heussler, Volker; Taracha, E L; Musoke, A; Duchateau, L; McKeever, D J (1998). Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva. Vaccine, 16(8), pp. 834-841. Elsevier 10.1016/S0264-410X(97)00263-6

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Cattle immunised with a recombinant form of p67, the major surface antigen of Theileria parva sporozoites, have been shown to be protected against parasite challenge. In an attempt to simplify the immunisation procedure live attenuated Salmonella strains expressing p67 have been constructed and used to induce anti-p67 immune responses in cattle. All animals immunised with these strains developed strong antibody responses to p67. Specific T cell responses could be detected in the majority of immunised cattle. Challenge with T. parva sporozoites revealed a significant level of protection in immunised calves compared to naive control animals or animals inoculated with non-recombinant attenuated Salmonella.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0264-410X

Publisher:

Elsevier

Language:

English

Submitter:

Volker Heussler

Date Deposited:

20 Jun 2016 10:35

Last Modified:

20 Jun 2016 10:35

Publisher DOI:

10.1016/S0264-410X(97)00263-6

PubMed ID:

9627941

BORIS DOI:

10.7892/boris.83738

URI:

https://boris.unibe.ch/id/eprint/83738

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