Transformation of leukocytes by Theileria parva and T. annulata.

Dobbelaere, D; Heussler, Volker (1999). Transformation of leukocytes by Theileria parva and T. annulata. Annual review of microbiology, 53, pp. 1-42. Annual Reviews 10.1146/annurev.micro.53.1.1

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Theileria parva and T. annulata provide intriguing models for the study of parasite-host interactions. Both parasites possess the unique property of being able to transform the cells they infect; T. parva transforms T and B cells, whereas T. annulata affects B cells and monocytes/macrophages. Parasitized cells do not require antigenic stimulation or exogenous growth factors and acquire the ability to proliferate continuously. In vivo, parasitized cells undergo clonal expansion and infiltrate both lymphoid and non-lymphoid tissues of the infected host. Theileria-induced transformation is entirely reversible and is accompanied by the expression of a wide range of different lymphokines and cytokines, some of which may contribute to proliferation or may enhance spread and survival of the parasitized cell in the host. The presence of the parasite in the host-cell cytoplasm modulates the state of activation of a number of signal transduction pathways. This, in turn, leads to the activation of transcription factors, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0066-4227

Publisher:

Annual Reviews

Language:

English

Submitter:

Volker Heussler

Date Deposited:

17 Jun 2016 08:30

Last Modified:

11 Sep 2017 18:14

Publisher DOI:

10.1146/annurev.micro.53.1.1

PubMed ID:

10547684

BORIS DOI:

10.7892/boris.83741

URI:

https://boris.unibe.ch/id/eprint/83741

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