Theileria parva: taking control of host cell proliferation and survival mechanisms.

Dobbelaere, D A; Fernandez, P C; Heussler, Volker (2000). Theileria parva: taking control of host cell proliferation and survival mechanisms. Cellular microbiology, 2(2), pp. 91-99. Blackwell 10.1046/j.1462-5822.2000.00045.x

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The intracellular parasite Theileria parva infects and transforms bovine T-cells, inducing their uncontrolled proliferation and spread in non-lymphoid as well as lymphoid tissues. This parasite-induced transformation is the predominant factor contributing to the pathogenesis of a lymphoproliferative disease, called East Coast fever. T. parva-transformed cells become independent of antigenic stimulation or exogenous growth factors. A dissection of the signalling pathways that are activated in T. parva-infected cells shows that the parasite bypasses signalling pathways that normally emanate from the T-cell antigen receptor to induce continuous proliferation. This review concentrates on the influence of the parasite on the state of activation of the mitogen-activated protein kinase (MAPK), NF-kappaB and phosphoinositide-3-kinase (PI3-K) pathways in the host cell. Of the MAPKs, JNK, but not ERK or p38, is active, inducing constitutive activation of the transcription factors AP-1 and ATF-2. A crucial step in the transformation process is the persistent activation of the transcription factor NF-kappaB, which protects T. parva-transformed cells from spontaneous apoptosis accompanying the transformation process. Inhibitor studies also suggest an important role for the lipid kinase, PI-3K, in the continuous proliferation of T. parva-transformed lymphocytes.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1462-5814

Publisher:

Blackwell

Language:

English

Submitter:

Volker Heussler

Date Deposited:

20 Jun 2016 10:39

Last Modified:

20 Jun 2016 10:39

Publisher DOI:

10.1046/j.1462-5822.2000.00045.x

PubMed ID:

11207566

BORIS DOI:

10.7892/boris.83744

URI:

https://boris.unibe.ch/id/eprint/83744

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