Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia.

Saguner, Ardan M; Ganahl, Sabrina; Kraus, Andrea; Baldinger, Samuel Hannes; Akdis, Deniz; Saguner, Arhan R; Wolber, Thomas; Haegeli, Laurent M; Steffel, Jan; Krasniqi, Nazmi; Lüscher, Thomas F; Tanner, Felix C; Brunckhorst, Corinna; Duru, Firat (2015). Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia. BMC cardiovascular disorders, 15(4), p. 4. BioMed Central 10.1186/1471-2261-15-4

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BACKGROUND

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is considered a progressive cardiomyopathy. However, data on the clinical features of disease progression are limited. The aim of this study was to assess 12-lead surface electrocardiographic (ECG) changes during long-term follow-up, and to compare these findings with echocardiographic data in our large cohort of patients with ARVC/D.

METHODS

Baseline and follow-up ECGs of 111 patients from three tertiary care centers in Switzerland were systematically analyzed with digital calipers by two blinded observers, and correlated with findings from transthoracic echocardiography.

RESULTS

The median follow-up was 4 years (IQR 1.9-9.2 years). ECG progression was significant for epsilon waves (baseline 14% vs. follow-up 31%, p = 0.01) and QRS duration (111 ms vs. 114 ms, p = 0.04). Six patients with repolarization abnormalities according to the 2010 Task Force Criteria at baseline did not display these criteria at follow-up, whereas in all patients with epsilon waves at baseline these depolarization abnormalities also remained at follow-up. T wave inversions in inferior leads were common (36% of patients at baseline), and were significantly associated with major repolarization abnormalities (p = 0.02), extensive echocardiographic right ventricular involvement (p = 0.04), T wave inversions in lateral precordial leads (p = 0.05), and definite ARVC/D (p = 0.05).

CONCLUSIONS

Our data supports the concept that ARVC/D is generally progressive, which can be detected by 12-lead surface ECG. Repolarization abnormalities may disappear during the course of the disease. Furthermore, the presence of T wave inversions in inferior leads is common in ARVC/D.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Baldinger, Samuel Hannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-2261

Publisher:

BioMed Central

Language:

English

Submitter:

Samuel Hannes Baldinger

Date Deposited:

30 Jun 2016 08:23

Last Modified:

03 Jul 2016 02:07

Publisher DOI:

10.1186/1471-2261-15-4

PubMed ID:

25599583

BORIS DOI:

10.7892/boris.83895

URI:

https://boris.unibe.ch/id/eprint/83895

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