Prospective longitudinal voxel-based morphometry study of major depressive disorder in young individuals at high familial risk

Nickson, T; Chan, S W Y; Papmeyer, Martina; Romaniuk, L; Macdonald, A; Stewart, T; Kielty, S; Lawrie, S M; Hall, J; Sussmann, J E; McIntosh, A M; Whalley, H C (2016). Prospective longitudinal voxel-based morphometry study of major depressive disorder in young individuals at high familial risk. Psychological medicine, 46(11), pp. 2351-2361. Cambridge University Press 10.1017/S0033291716000519

[img] Text
download.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (235kB) | Request a copy

BACKGROUND Previous neuroimaging studies indicate abnormalities in cortico-limbic circuitry in mood disorder. Here we employ prospective longitudinal voxel-based morphometry to examine the trajectory of these abnormalities during early stages of illness development. METHOD Unaffected individuals (16-25 years) at high and low familial risk of mood disorder underwent structural brain imaging on two occasions 2 years apart. Further clinical assessment was conducted 2 years after the second scan (time 3). Clinical outcome data at time 3 was used to categorize individuals: (i) healthy controls ('low risk', n = 48); (ii) high-risk individuals who remained well (HR well, n = 53); and (iii) high-risk individuals who developed a major depressive disorder (HR MDD, n = 30). Groups were compared using longitudinal voxel-based morphometry. We also examined whether progress to illness was associated with changes in other potential risk markers (personality traits, symptoms scores and baseline measures of childhood trauma), and whether any changes in brain structure could be indexed using these measures. RESULTS Significant decreases in right amygdala grey matter were found in HR MDD v. controls (p = 0.001) and v. HR well (p = 0.005). This structural change was not related to measures of childhood trauma, symptom severity or measures of sub-diagnostic anxiety, neuroticism or extraversion, although cross-sectionally these measures significantly differentiated the groups at baseline. CONCLUSIONS These longitudinal findings implicate structural amygdala changes in the neurobiology of mood disorder. They also provide a potential biomarker for risk stratification capturing additional information beyond clinically ascertained measures.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Papmeyer, Martina


600 Technology > 610 Medicine & health




Cambridge University Press




Martina Papmeyer

Date Deposited:

20 Jul 2016 10:04

Last Modified:

22 Dec 2016 13:57

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Amygdala; bipolar disorder; hippocampus; major depressive disorder; voxel-based morphometry




Actions (login required)

Edit item Edit item
Provide Feedback