Intracellular survival of apicomplexan parasites and host cell modification

Lüder, Carsten G K; Stanway, Rebecca R; Chaussepied, Marie; Langsley, Gordon; Heussler, Volker (2009). Intracellular survival of apicomplexan parasites and host cell modification. International journal for parasitology, 39(2), pp. 163-173. Elsevier 10.1016/j.ijpara.2008.09.013

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The intracellular stages of apicomplexan parasites are known to extensively modify their host cells to ensure their own survival. Recently, considerable progress has been made in understanding the molecular details of these parasite-dependent effects for Plasmodium-, Toxoplasma- and Theileria-infected cells. We have begun to understand how Plasmodium liver stage parasites protect their host hepatocytes from apoptosis during parasite development and how they induce an ordered cell death at the end of the liver stage. Toxoplasma parasites are also known to regulate host cell survival pathways and it has been convincingly demonstrated that they block host cell major histocompatibility complex (MHC)-dependent antigen presentation of parasite epitopes to avoid cell-mediated immune responses. Theileria parasites are the masters of host cell modulation because their presence immortalises the infected cell. It is now accepted that multiple pathways are activated to induce Theileria-dependent host cell transformation. Although it is now known that similar host cell pathways are affected by the different parasites, the outcome for the infected cell varies considerably. Improved imaging techniques and new methods to control expression of parasite and host cell proteins will help us to analyse the molecular details of parasite-dependent host cell modifications.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0020-7519

Publisher:

Elsevier

Language:

English

Submitter:

Volker Heussler

Date Deposited:

06 Jul 2016 11:11

Last Modified:

07 Jul 2016 04:35

Publisher DOI:

10.1016/j.ijpara.2008.09.013

PubMed ID:

19000910

BORIS DOI:

10.7892/boris.84070

URI:

https://boris.unibe.ch/id/eprint/84070

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